Hi Gasgirl,One of the archive posts about Cilansetron that you refer to may have been mine. It's been awhile since I reported on my progress with Cilansetron. While I'm never sure how much information to report, I can tell you that since going on the open-label phase (in January, 2002) I have been almost symptom-free. No 'D', no bloating, no panic-rushes to the bathroom. This stuff works great for me. Once in awhile I have a little nausea right before I eat but it goes away quickly. There is a tendency to constipate so I had to change my diet to include more fiber which I should do anyway. I am currently taking 2mg three times daily. As I had reported earlier, I have never had really severe symptoms, but I've always had 'surprise' visits by Mr. 'D' at the wrong time or very strong urgency. At the 'open-label' phase follow-up visits are every 3 months for one year. I'm not sure what the timetable for approval is, but I'm hoping I can be extended if FDA approval isn't forthcoming. I hope this info helps you. If you have additional questions, I'll try to answer offline. I never took Lotronex so I can make any comparisons, but I suspect that Lotronex was/is more effective for intense or prolonged symptoms. I would have to say that this is the first time I have had sustained relief in over 12 years of IBS. I can't say enough good stuff about Cilansetron. I concluded that for the first 18 weeks I took the placebo because once I started on the open-label, I had relief on the third day. I hope you find what you need with the study and that it offers you relief. Good luck.~bigjon kc