Hi, I am new on this board. I have been in the Cilansetron open label study for 7 months. Before that I was in the blind study for 3 months. I am male. The Cilansetron works very well for me. It is not perfect but is real close. It has almost completely ended my D/Urgency. I am taking 2mg, 3 times/day. It has made my life completely normal again for the first time in 9 years. BigD, I see you are in LA. I have been going to Orange to participate in this study. Maybe your doctor is referring to studies in LA starting next year but this one is going. You should call the 1-877-DIGEST1 number to find out if they are still taking people. It is worth the drive to Orange for the Cilansetron.So my answer to Gutt-n-Butt is that this med is great, at least for me. I donï¿½t ever want to stop taking it.