I was diagnosed with IBS about 6 years ago. I would have gas and cramping once or twice a month and thats it. The doctor (GI)wrote me a prescription for Hyoscyamine. I would take them as needed. I now have the gas and cramps everyday. It doensn't matter what I eat,(I'm a vegeterian)I still have the cramping and gas everyday. I had a colonoscopy in 2006 and it was normal.I thought I might have Celiac(might not be spelled right)problem, so I cut out all the wheat bread and bought some wheat and gluten free breads. Eating the wheat and gluten free bread did not help.