About a year ago I visited this sight in search of help for my 68yo Dad, and I want to share the news for anyone it may help. He was having severe constipation and has had maybe 2 bowel movements since March that were not induced by an enema, which he resorted to after the failure of Citacel, metamucil, senna tea, suppositories, stool softeners, laxatives, miralaxï¿½ the list goes on. With the accompanying bloating, gas, stomach pain and weight loss, the man was miserable with no quality of life. It also affected his bladder function. (note: he was initially trying to lose weight. Lost 50 lbs, stopped trying, lost 20 more. This all started while he was trying to lose weight.) After numerous CT scans, MRI's, blood tests, manometry, biofeedback, unsuccessful defacagrophy(sp), none of the doctors would even venture a diagnosis. In November, I stumbled across an article about Botox being used to relax the sphincter muscle. We were able to get into IU Medical Hospital for a follow-up colonoscopy and the Dr. there was willing to try the Botox. During the colonoscopy it was noted that his colon was enlarged- approx 8 inches in dia. I think he was ingesting sufficient fiber! It took about 10 days(he was scheduling surgery!) and he has now had 9 unassisted bowel movements in 8 days! My Father is laughing again for the first time in a year! I was afraid he was going to have his colon removed...which is all the local Dr.s ever suggested. Another topic I stumbled across in this journey and may be of interest to you is called "Ogilvie's Syndrome". Google it. It is a parasympathetic disorder associated with electrolyte imbalance among other things. My dad was drinking a gallon of water a day and was still dehydrated. Switch to Gatorade!I wish you all the best and hope this can help someone. I know how frustrating this ordeal can be. If you're not getting answers, find another doctor!