I’m a new member and I’m feeling really desperate and hope that someone out there can help me. I’ve been reading this forum for a long time but never contributed before and I’d like to thank you all so, so much for being so candid, sympathetic and helpful. I’m 59, a married professional woman with one child who lives in the Boston area. I’ve had IBS-D for about 3 years now. I also have acid reflux and take prilosec for it every day. I’ve been seeing a gastroenterologist and he has done a million tests including a colonoscopy and have ruled out any possible diseases, tumors, parasites, etc. that might be causing it. I go the bathroom 6 to 10 times a day. I needed to completely evacuate in the morning or I will go in my pants which has happened several times. I have loose stools, not diarrhea but I can’t hold them in. Therefore, several times a week I take one immodium before I left the house. This drug was a lifesaver and after taking one immodium I could eat whatever I wanted and would not have to go to the bathroom at all for the rest of that day. However, it took me several hours to finish up going to the bathroom and I was showing up for work at 3 in the afternoon and eventually lost a job that I loved. About a year ago, my doctor suggested I give up coffee (as well as decaf) and eliminate dairy products from my diet. Much to my delight, this seemed to work very well and I had normal movements for about a year. (I started drinking cafix which is a barley based beverage in the morning with lactose free creamer in the morning). However, about a month ago, the diarrhea problem began coming back. I started using immodium again almost on a daily basis and it worked perfectly until last week. Now I’m really desperate because the immodium does not seem to be working any more and in fact I’m afraid it’s causing me to have the runs. Has anyone else had this problem? I took an immodium and went out with my daughter last week and had a couple of bites of a cookie and by the time I got home I had the runs. This also happened Saturday night. I felt very gassy and upset to my stomach before this happened. I never had this experience before with immodium usually when I take it I don’t have to go at all until the next day and in fact sometimes feel bound up for a few days afterward. Needless to say, I took a second immodium after this. I’m not sure if the second immodium worked because it was at night and I didn’t go out after. I’m going to see my gastroenterologist tomorrow and wanted some suggestions on what I should say to him to make sure that I ask the right questions. Are there any new treatments that people are having success with? Are there any diagnostic tests that I should be taking? Thank you so much!