I will make this post short and sweet. I have had very bad IBS-D for over 30 years. I have done all the tests, elimination diets, and had tried all medications with no effect. I used to always be on this website looking for cures. Finally I got so discouraged I was just bound and determined that I would have to live with it. After I turned 40, it got much worse and was severely disrupting my life. I started noticing a large amount of bile in my intestines anytime I would have a BM. I have always had horrendous gas with the bile discharge (sorry for the grossness - but I want to help others). Finally one day I decided to look into those symptoms. After some research - BAM (bile acid malabsorption) really caught my eye. Mayo Clinic had an article that 1/3 of IBS is BAM that goes undiagnosed. That being said, I was skeptical that my answer would be that easy after all of these years. I reluctantly decided to try cholestyramine - but with little hope it would work. For perspective - I have not had a solid bm in over 30 years (no joke). My IBS was BAD (10 out of 10). After one day on cholestryamine - everything changed instantly. The cramps and diarrhea came to an abrupt stop. The second day I had no BMs (usually I have 6-10 a day). The third day I had normal, formed, BMs. And it has continued for a full week with no IBS symptoms at all. I cannot believe it. I have my life back. All thanks to a cheap medication that I mix with applesauce. I know this doesn't apply to all - but please, please, please, - if you have IBS D and mirror any of my symptoms.....try this medication. It might change your life like it did mine. I FEEL LIKE I WAS BORN AGAIN. I cannot even contain my happiness and excitement. I hope you all find your solution too. I should note that I do not have any gallbladder problems.