I was on this one. It does kill the pain in fact I didn't feel a thing. No pain, nothing.The only thing that was bad was I kept crying. I quit this one becasue of that. I wasn't constipated since I am mostly D thanks to no gallbladder and nerves, I had nice BM's. Was proud of them.Good luck!P.S.- this is suppose to be similar to Effexor.