Well, I just looked at the pharmacy information from the Cymbalta website. During clinical trials, 11 people got constipated while 8 people had diarrhea, so it's about even. I think that it really depends on your body. Zelnorm was supposed to help me go, but I got more consitpated, so you almost have to try the medication before knowing what it's going to do. Finally, after a couple of weeks on Magnesium Citrate, I seem to be going a little every day now instead of once a week. So, if Cymbalta ended up slowing your motility down even more, there are other options that can help you move. Magnesium, Zelnorm, dulcolax, etc. If you think Cymbalta can do you good mentally or in pain control, I'd go for it. If you don't like the side effects, you can always discontinue the medication later. It look like something I might try eventually considering I have daily pain, and a varying amount of depression.