Hi Debbie, I've been on Lotronex for five weeks now. My ibs didn't produce D every day. My problem was urgencey, when I had to go, I HAD to go! One minute I'm fine, the next I'm in a panic looking for a bathroom. Lotronex has greatly improved this condition, along with caltrate, probiotics, and fiber. I have trouble with fiber supplements. Most have sugar or worse, nutrisweet, which worsens my ibs. So I eased fiber into my diet from whole foods. At first I has alot of gas and bloating, but that decreased over time. As far as the C goes, this is a new experience for me. Before, if I didn't have three BM's before noon, I thought I was constipated. When you're used to being empty, it feels weird not to be. But I hung in there and I'm glad I did. I'm having more good days than bad, and the bad days are more managable. I see light at the end of the tunnel. If you're taking Lotronex, and it's not making you real sick, try to stick with it a while longer. Good luck!