My mother passed away Nov. 30, 2002 after a month of suffering from cancer. It was extremely unexpected and tramatic. Since that time I have gone through terrible depression. I had been on Effexor for my IBS-D, but that didn't work on the new depression. The dr. switched me to Lexapro. That didn't work, so he put me on Zoloft. Last week he upped my Zoloft dose to 200 mg. I felt like I had a rock in my stomach and was having some labored breathing. I dropped back to 150 mg and soon got rid of the unpleasant side effects. I have added 150 mg. of Effexor to the Zoloft. At first I was nauseous, but it's going away. Does depression from grief ever subside, or will I be on these meds forever?