My doc just put me on 25mg of Desipramin taken at bed time.My "IBS" problem is I have a slightly loose BM but the real problem is I spent 3-4 hrs in the bathroom because I do not "go" or "complete" all at once, just alittle at a time. (I don't think any doc Ive seen understands this).Ive been on Lexapro- it made my D horrible and did not improve my bathroom in-out time.I was on Librax and it seemed to help at first but in the end didn't really do much of anything for me other than put me in a bad mood all the time.Im wanting to know what to expect with the desipramin and if anyone has had any luck with it?I am to the point where I could careless if its D I just dont want to be spending 4 hrs every morning in and out of the bathroom.