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I've used Desipramine for the last year or so at 10mg/day. Like any antidepressant the initial side effects, namely tiredness, dry mouth and lack of concentration, passed rather quickly. At times it helped take the edge off the pain and D for me. The increase in dosage would probably be better for me because pain is still an issue in the mornings.Good luck. I hope you find some benefit from it.Jeff
