Yes KLF, I am taking Prozac, and it does help with the seritonin level in your brain. IF it be any help, my family physician diagnoised me with IBS too, and recommended see a nutritionist at the hospital and also taking Metamucil, because of the fiber. If you do have any side affects from Prozac, let your doctor know, sometimes it takes a few weeks before the medication gets adapted to being in you. It made me sleepy all the time so I take it before I go to bed, so I don't have that problem in the day. I hope this will be some help too you-Good Luck!