Otilonium Bromide (OB) 40 mg seems to be a good candidate for gut pain as it acts directly on smooth muscle cells. It is superior to placebo. It is known as spasmomen by its manufacturer A. Menarini Industrie Farmaceutiche Riunite Srl in Italy, http://www.menarini.com/ethical_division/t...l_area/products .The risk for adverse effects such as ischemic colitis or severe constipation may be over emphasized for Lotronex (alosetron) used for IBS-D. There are reportely 1.1 case of ischemic colitis per 1,000 patient years and 0.66 cases of complicated constipation per 1,000 patient years. It is not clear why more US-based doctors do not prescribe this for their patients.Probiotics seems to increase mucous production and modulation of the immune system amongst its many properties. It decreases TNF-alpha, IFN-y and IL-8 while increasing IL-10.There is little good research data on the use of probiotics for IBS. B. Infantis showed benefit in only 2 out of 5 studies. VSL#3 appears to improve flatulence and retards colon transit time.There is virtually no reserch data on the long term effects of probiotics usage.The number of microbia cells in the human body outnumber the host cells by 10-fold.The antibiotic effect on the microbiota is significant such that it takes months to return the gut to the same microbiota as before antibiotics. The same species will be replaced; however, not necessarily in the same quantity.Patients with Irritable Bowel Syndrome are unnecessarily prescribed narcotics.http://www.medicalnewstoday.com/articles/187476.php
Mayo Clinic Researchers Discover New Genetic Candidates for Irritable Bowel Syndromehttp://www.medicalnewstoday.com/articles/187632.phpIronwood Pharmaceuticals, Inc. and Forest Laboratories, Inc. presented Phase 3 clinical trial results assessing the efficacy and safety of the investigational drug linaclotide in patients with chronic constipation (CC). Lincaclotide is in Phase 3 clinical development for the treatment of irritable bowel syndrome with constipation (IBS-C) and CC.http://www.medicalnewstoday.com/articles/187645.phpNo Magic Cures for IBS: Brennan Spiegel, MD, of the University of California Los Angeles, spoke with MedPage Today senior editor John Gever about the advances reported at Digestive Disease Week in understanding and treating IBS. http://www.medpagetoday.com/MeetingCoverage/DDW/19944 (video)
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