I was getting ready to post this yesterday when I had to leave my computer to run to the bathroom. I had been experiencing really bad abdominal pain and my stomache bloated up like a balloon all day. Nothing new to me, I have had IBS for years (going on 10 yrs). It was unfortunately a severe "episode" as I call them. I was having the pain but couldn't have a bowel movement which is unusual as I have IBS-D. I was doubling over with pain waiting to go to the bathroom. Finally as i was checking this forum, the pains started again; so bad, that I used my lamaze breathing technique (it's one that I learned 20 years ago when experiencing childbirth). It helps calm me down. I ran to the bathroom leaving my computer on and after half an hour of this, finally was able to move my bowels. Of course, once started they couldn't stop. I had to take Darvocet (pain killer) just to ease the pain. I was so exhausted afterwards, that i could not get back to my computer or anything else for that matter. I am disappointed again, as 30 days ago I was placed on Lotronex by my doctor. I was really hoping it was the drug that would help (along with being careful what I eat). It did help with diarrhea but if that's all it does, then I might as well take my Lomotil... it does not cost as much. I see the doctor for a follow up next week as he is on vacation. I guess I am just frustrated again as I felt so optimistic when I was given this prescription hoping it would make my IBS manageable, and now am disappointed and depressed. I have had several episodes since taking the medication but they were not as severe. Yesterday's doozie just set me back emotionally and physically. Has anyone else experienced an expectation when trying something new just to find out it is a disappointment? How do you keep your optimism?