Dizziness..........

Yes it only last 1 second.The heat is a factor of exhaustion.Asiana

Intraganglionic laminar endings (IGLEs) represent the most prominent vagal afferent terminal structures throughout the gastrointestinal tract. They are most prominent in the esophagus and stomach, but can be found down to the distal colon. (IGLEs) associated with myenteric ganglia, supplied colonic myenteric ganglia, the proportion of which decreased from 50% in the caecum to 15% in the distal colon. Their role as mechanosensors as proposed on anatomical grounds was recently substantiated. A study was aimed at detecting purinergic receptors on IGLEs. Terminal nerve fibers immunoreactive for P2X2 and P2X3, respectively, were observed between outer and inner layers of the tunica muscularis, covering myenteric ganglia totally or partly. Their mechanosensory properties may be modulated by ATP. Cell-cell communication via released ATP and Ca(2+) signaling in the cellular network , were examined. ATP-release and Ca(2+) signaling were cell-shape dependent, i.e. they were further enhanced in flattened cells treated with endothelin. Since Ca2+ contributes to the activation of contractile proteins (actin), these findings suggest a contribution from the actin cytoskeleton on ATP-release in subepithelial fibroblasts. The released ATP activates Purine (P)2Y receptors on the surrounding cells and propagates Ca (2+)-waves through the network and also activates P2X on terminals of mucosal sensory neurons. Vagal primary afferent neurons that respond to luminal stimuli, contain mainly P2X receptors. These neurons appear to play an important role in the mediation of the vago-vagal reflex elicited by luminal stimuli. This results in a late vagal inhibition of the RVLM, (to be discussed below). The number of dorsal root ganglion (DRG) neurons responding to ATP and the number of those staining for the P2X3 receptor, were increased after application of ATP. DRG neurons project to the parabrachial nucleus (PBn) via the spino-parabrachial pathyway. Visceral afferents (activated by colon distyension) project to the parabrachial nucleus (PBn). Electrical stimulation of the lateral regions of the PBn complex resulted in a site-specific increase in GABA concentration in the dialysate collected from the NTS (NUCLEUS TRACTUS SOLITARIUS). The temporal increase in extracellular GABA concentration in the NTS coincided with the time course of PBn-induced cardiac BRR (baro-reflex response) inhibition, (suppression of reflex bradycardia). The responsiveness of PBn neurons activated by CRD (colo-rectal distension) was lower in PBn neurons antidromically driven from the central nucleus of the amygdala (CeA--activated by coffee). These results suggest that a reduction of a GABAergic descending projection of the lateral PBn would decrease activation of GABA receptors at the NTS, resulting in bradycardia. Microstimulation of the NTS induced antidromic compound spike potential along the ADN (aortic depressor nerve). Stimulation of ADN afferents and late vagal inhibition facilitated inhibition in rostroventrolateral medulla (RVLM--involved in blood pressure regulation) neurons, and the average duration of inhibition exceeded the duration of the cardiac cycle. This would result in a measurable bradycardia and an electronic pulse meter was used to investigate this response. It gave a beat by beat, instantaneous reading of the pulse rate. I have a procedute that I can’t describe (due to sexual references) that induces colo-rectal distension. There is a palpable decrease in heart rate. Bradycardic readings (37.9 beats per minute) associated with my induction procedure were slower than the baseline--103 bpm.I would suggest to Asiana to not drink coffee after your morning BM, and if you get dizzy or faint headed, to lie down and massage your colon.

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quote:I have a procedute that I can’t describe (due to sexual references) that induces colo-rectal distension. There is a palpable decrease in heart rate. Bradycardic readings (37.9 beats per minute) associated with my induction procedure were slower than the baseline--103 bpm.

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Wow,you do research on the vagus nerve or something?I like that but i have to reread to understand.