I'm in my late sixties and my right knee is really bothering me lately. It's stiff and kind of painful, but if I rest it's somewhat better. I've stopped taking walks, since that also makes it hurt. My husband takes glucosamine for his painful joints and it really helps him. So did my mother when her knee used to bother her. It's supposed to really help with arthritis and also help to rebuild cartilage.But I read somewhere that one of glucosamine's side effects is heartburn. I take Nexium each day, but only 20 mg. (doctor's orders to reduce the dosage...it's a long story). I really need to take care of my knee, because (as many of you here know) with the serious antibiotic allergies I have, doctors tell me I'm a surgeon's nightmare. They say it's risky to do surgeries on me without antibiotics, and also risky to use them with me, so it's a bummer either way. (There's a fairly high risk of staph infection after knee surgeries too, and a friend of mine died after having knee surgery (due to staph). So I have some emotional baggage to deal with on this too.The most sensible thing to do would be to take glucosamine, but I don't want my GERD to get worse either.Any of you with GERD taking glucosamine successfully? I could use some encouragement and advice.