I have been taking Sulfasalazine for almost a year. I take 4 pills in the a.m. and 4 pills in the p.m. equalling 4000mg daily. I was diagnosed with ulcerative colitis last summer and was initially put on Asacol. It made me more ill. My doctor stopped the Asacol and placed me on Prednisone ### 30mg. daily after 20mg. did nothing. Fortunately the Prednisone and Sulfasalazine worked. Within three weeks I was symptom free after suffering with the worst of colitis symptoms. My doctor was unsure if my asymptomatic status would remain after he weaned me off Prednisone. He did so VERY slowly. Since Christmas I have not been on Prednisone and have remained symptom free. I have learned so much about this disease from Dr. Stephen May who contributes personal answers to questions/concerns expressed on the "Ask The Specialist" forum of the Crohn's and Colitis Foundation of America website. His help has been a Godsend! In addition to the Sulfasalazine I also take all the recommended (by Dr. May) vitamins and supplements. It works for me. Good luck! Cecile