I hope your doc is right. I saw my GI doc this weekend and when I asked him if Lotronex was coming back, he said something like, "I can't imagine that it would". That was very discouraging. I told him about this board and that we had been hearing very positive news and he seemed very interested in that. He did say also that the drug reps for Zelnorm are still talking like it will sometime get approval.I sincerely hope Lotronex makes a comeback. I'm coming off a terrible flare with the IBS and I hate taking immodium everyday, but the calcium and my diet just aren't cutting it.I'm going to try to stay positive though. I think there is reason for it.