Hi hateibs,I have taken Zoloft and found it made me too tired but other people have no problem with it. Also when I went off if (Zoloft) it make me really sick for a few days. It really depends on how you body reacts to it. I take Buspar for my nerves it works well for me. Have you seen a Gi? I ask that because my Gi has me on a antispasmodic (Donnatal) that really helps me with the D.