Does anyone know if estrogen (specifically Premarin) has any effect on IBS-D? I developed IBS shortly after a complete hysterectomy about 16 years ago, and when I asked my surgeon if there could be a connection he only laughed. I always figured the surgery had something to do with it but now I wonder if maybe the Premarin could be at fault. I take a very small dose - .0625.If anyone has any knowledge as to a connection between IBS-D & Premarin I would appreciate comments. Thanks to anyone who can help.