You betcha IBS makes you tired!Gut spasms, gas, abdominal pains, plus all that fun time spent either on the toilet or running to it can really wear you down.Not to mention the anxiety, embarassment and general stress of IBS.Yep, all that can make you tired, plus, some meds, like Levsin, make you drowsy, with dry eyes and mouth and swollen hands and feet.Like the other posters recommend, I 'd get the fatigue checked out to make sure it's not something else, but yes, IBS alone can take a lot out of you - figuratively and literally!!!