My doctor gave me Doxepin to try. He said he had his best results with it for IBS patients and prefers it over the other anti-depressents because it causes less lower GI side-effects than the others in the first few weeks of treatment. Since I tried so many things (but never anti-depressents) before this, I was very skeptical that it would work. I was basically humoring him when I agreed to try it.The first week was hell. It made me so tired I hardly was able to drive to work. And in the morning I got nauseous. And my IBS was as bad as ever. I called my doctor hoping he would take me off it, but he encouraged me to keep trying because it takes a couple of weeks for it to start working. So I cut down the dose to half a capsule and that was still hellish. Then I tried 1/3 of a capsule, and the side effects went away. Every week I added a little more, until I reached a full capsule.And guess what? It's working! I think my IBS is better than it has ever been. I still have some bad episodes, especially if I eat bad, but usually I am normal. It was only a couple of months ago that my 10 minute drive from work was filled with fear because I would almost always suddenly need the bathroom. But now I haven't had to panic even once for maybe a month. The side effects seem pretty good so far. I feel a little tired during the day, but not nearly as bad as I get on allergy medicines (even the non-drowsy ones). And my dreams are very vivid, but this isn't a bad thing to me.It seems too good to be true, and I am sooo worried that this is just a good phase that I'm going through and has nothing to do with the Doxepin. But if it lasts, then it is truly a miracle!The lesson here is if anybody reading this is trying these types of drugs, don't give up until you have given it a lot of time, because they don't start working right away.