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Discussion Starter · #1 ·
Hello All!I have IBS-CDue to the severe spams in my belly and small intestine.. causing vomiting, I was put on Levsin almost 2 weeks ago and I cannot function at all. I am so drugged, that I'm almost incoherent. The dilatation of my pupils render focusing impossible, I can't concentrate on a conversation, heck I can barely hold my head up. Today I decided not to use it to clear my head and am so weak from being flat and (vomiting from the IBS) that I've lost a tremendous amount of ground with my health. I have recently lost 15 pounds which puts me into an anorexic state and I fear without the Levsin I will continue to twist in my belly losing all my nutrition. The Levsin DOES help the spasms.I have used Librax which doesn't do a thing for me but cause me to go cross-eyed sleepy.Bentyl is a just a more expensive brand of Librax.Some Docs say that Levsin and Levbid are the exact same drug.... but Levbid is hyoscyamine hydrochloride and Levsin is Hyoscyamine sulfate. Totally different in my nurse opinion don't you think?I need a antispasmotic with fewer symptoms. Do any of you know of one? Thanks so much,Belinda
 

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Wow i feel really bad that you are having all these side effects. I take 2 .125 MG tablets of levsin in the morning after breakfast and 2 after lunch. Actually it is Hyoscyamine generic. I didnt know about those two different forms of Levsin so thanks for the info, ill be sure to ask my specialist about it. The only side effect I get from the Levsin is dry mouth and I really think that it does stop most of my spasms within about 30 minutes. I tried Bentyl but that did nothing and just made me feel like ####. I just like how the tablets seem to work a lot faster and target the lower GI symptoms. Even if the spasms still continue, I noticed that now i can actually expell some of the gas and they stop. Before medication I could never do that. However since 4 tablets is the max I have to feel the symptoms in the evening as a price to pay for feeling better during the day. Always curious if others are seeing the same success.
 

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Discussion Starter · #4 ·
Hi Mike,Wow I wish I could be just like you. My worst moments are in the evening.... breakfast is the only meal I can really take without problems. The Levsin is true relief for passing gas, what a delight to finally pass that nasty painful stuff. My belly swells to the point of being shiney, like being 9 months pregnant. And the spasms are visible, looks like I have an anaconda writhing in my stomach. I am on Levsin 0.125 SL 1 every 6 hours, the sublingual works VERY fast but my side effects don't wear off for 5 hours and then it's time to go again. I actually get an accumulative effect. Tonight I'm going to try a half of a pill to see my reaction. Jackie what is Pamine?
Belinda
 

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Pamine is an anti-spasmodic that is supposed to have fewer side effects because it doesn't effect the central nervous system. Here is some info
quote: Pamine� Rx Only (methscopolamine bromide) The discomforts of bloating, diarrhea, cramps and other related GI problems caused by hypermotility (increased muscular activity in the GI tract) is, in fact, a fairly common condition. Statistics show that as many as 20% - 30% of the general population experience these symptoms on a regular basis.Pamine� helps relieve the pain associated with bloating, diarrhea, and cramps by slowing the motion of the GI tract. Safe, effective, and time-tested, Pamine� reduces the amount of acid in your stomach, thereby reducing the pain associated with excessive stomach acid. And, unlike some anticholinergics/antispasmodics that contain substances that cross the blood-brain barrier and enter the Central Nervous System (CNS), Pamine� has not been shown to penetrate the blood-brain barrier and has no significant CNS effects. Using Pamine�, therefore, genuinely minimizes the risk of significant central effects such as light-headedness or fatigue.
quote: METHSCOPOLAMINE - ORAL(meth-sko-PALL-uh-meen) COMMON BRAND NAME(S): Pamine USES: This medication is used in combination with other drugs to treat peptic ulcers. OTHER USES: This drug may also be used for stomach/intestinal spasms, to decrease salivation, to reduce stomach acid secretion and may be used for other purposes as determined by your doctor. HOW TO USE: Take as directed, usually 1/2 hour before meals and at bedtime. The dosage will depend on your condition and your response to this drug. Your dosage may be adjusted by your doctor. Do not take bigger doses or more frequent doses than prescribed by your doctor. SIDE EFFECTS: Constipation, dry mouth, trouble urinating, nausea or dizziness may occur. If these effects persist or worsen, notify your doctor promptly. Unlikely to occur but report: increased pulse, diarrhea, eye pain, vision problems. In the unlikely event you have an allergic reaction to this drug, seek immediate medical attention. Symptoms of an allergic reaction include: rash, itching, swelling, dizziness, trouble breathing. If you notice other effects not listed above, contact your doctor or pharmacist. PRECAUTIONS: Before taking this drug tell your doctor your medical history, especially of: glaucoma, all eye problems, heart disease, enlarged prostate, stomach/intestinal disease, liver disease, kidney disease, high blood pressure, drug allergies. Because this drug decreases sweating, heat stroke or fever may occur if you are exposed to high temperatures. Since this medication may cause drowsiness, use caution engaging in activities requiring alertness such as driving or operating machinery. Elderly patients may be more sensitive to the effects of this drug. Use cautiously. This medication should be used only when clearly needed during pregnancy. Discuss the risks and benefits with your doctor. It is not known if this drug is excreted into breast milk. Consult your doctor before breast-feeding. DRUG INTERACTIONS: Tell your doctor of all nonprescription and prescription medication you use, especially of: antidepressants (tricyclic type), MAO inhibitors (e.g., phenelzine, linezolid, tranylcypromine, isocarboxazid, selegiline, furazolidone), quinidine, amantadine, antihistamines (e.g., diphenhydramine), other anticholinergics, potassium chloride supplements, antacids, absorbent-type anti-diarrhea medicines (e.g., kaolin-pectin), phenothiazines (e.g., chlorpromazine, promethazine). Do not start or stop any medicine without doctor or pharmacist approval.
My son has been on both Levsin and Bentyl. Bentyl worked well, but he didn't like the side effects. He feels that Pamine works just as well without making him tired. When he's having an especially bad time, he switches over to Donnatal. Donnatal works great for him, but it has a barbituate, so we don't like him to be on it too long.
 

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Discussion Starter · #6 ·
JackieGian,Thank you for the info on the drug Pamine. The Levsin has been such a scary ordeal for me that I'm getting quite frightened of the antispasmotics. Even tho the Pamine doesn't cross the threshold and upset my CNS, it still has alot of the same side effects. Only I can get them all, I swear! My reaction with the Levsin started within 30 minutes after dissolving under the tongue... first the spasms would ease, in an hour I get a heavy chest, shortness of breath, palpatations and weakness. In 2 hours it turns to dilated pupils, inability to focus, no concentration, dizzy, faint feelings, confusion, etc.... In 5 hours it starts to subside then it starts all over again with the next 6 hr dosing. I took 1 0.125 Levsin at 8:30 last night to help with the night spasms and ended up vomiting anyway. This morning I had a terrible drug hangover, and right now I'm still not feeling well. I threw the Levsin in the garbage. It almost felt like throwing out my only salvation, but with my reaction I believe the drug would eventually kill me. I'm afraid of even going out into the public for fear of catching a virus or worst this deadly flu.... I have no defenses to fight at this time.Do you know of safe enzymes that might help with digestion in the mean time?Thanks in advance,Belinda
 

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Definitely talk to your doctor about this, but I haven't had the same problems with Levsin. I do have super dry mouth at times, and when I first started the drug I had a little bit hard of a time with reading as I would find it hard to keep my eyes in focus totally, but after a few weeks my eyes adjusted to it, and I didn't have any more problems. Still have dry mouth, but all of the other symptoms are gone. Perhaps if you just stick with it for a bit, your body will adjust.
 

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Belinda,I don't blame you for being frightened. Those side effects sound pretty serious to me. You should definitely speak with your doctor about them. I know the Pamine lists the same side effects, but my son didn't experience any of the effects with Pamine as he did with Bentyl or Levsin. It may be worth a try.The only natural thing I can suggest would be probiotics, but they have limited effectiveness.
 

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Discussion Starter · #9 ·
I threw the Levsin in the garbage and will tell my GI specialist... I've been taking it for 2 weeks 1 every 6 hrs during waking hrs as advised by my MD. Unfortunately the accumulation of the drug had taken over and I was in a stupor of "giving up or not caring about life" scared my mother who is here to help me for a few weeks.... I'm 40 and have been a nurse for 20 yrs.... you'd think I'd be bright enough to catch the bad effects sooner! I guess a nurse is like a mechanic...drives the worst body/car in town.It's been almost 24 hrs since my last dose and I'm still feeling effects. I wish my body could tolerate meds like most of you out there and could find peace with spasms and the big C.I hope that someday I will be well enough to return to work. I've been unable to work now for almost a year.
 
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god, your symptoms are so similar to mine. i too have visible spasms in my gut. its really bad. i'm at work right now but will write more. levsin is the only thing that has worked for relieving the gas buildup. peppermint - enteric coated can also work, but i found it gave me bad gerd. i got acummulative effects with levsin as well and could not tolerate it
 

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Discussion Starter · #11 ·
joanofarc,Wow another with a live Anaconda in the gut!!! I thought I was alone in this crazy thing. I'm sorry to hear you had troubles with Levsin also. I'm on Miralax for the C and am hoping that will help with pushing EVERYTHING through and maybe resulting in fewer spasms. I started it the same time I did the Levsin, so I really don't know which helped release the gas. Guess I'll find out soon without the Levsin. My C was so bad that after I started the Miralax 2 weeks ago.... I passed barium that was still held up in my bowels since August. Scary huh? Hopefully I won't feel like such a poopy person anymore! LOL
 

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quote:Wow another with a live Anaconda in the gut!!! I
You obviously don't have IBS. The vomiting also suggests pseudo-obstruction.
 

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Discussion Starter · #13 ·
Flux,What do you suggest I have? My GI stated I had IBS. My GP in Montana would love to cut me open AGAIN and hunt for the infamous adhesions. (which I have trillions of) But as we know adhesions are usually done forming 2 weeks after surgery which has been 10 yrs since my last abd cut about. These 'anaconda twists' started late this spring and I've had bowel problems since I was 19 (21 yrs ago)I'm desperate for answers since I'm so sick and have lost so much ground with my health. I've had another upper GI series in Aug and no obstruction has been found. Now 10 yrs ago I had 3 abd surgeries in 7 months.... female stuff and internal bleeding with gross amts of adhesions forming. The second surgery they went witch hunting and didn't fix my problem which was low and behold a partial obstruction around my colon by an adhesion. (after doing the correct tests to locate it, duh) Then the third surgery took out EVERYTHING female but my gallbladder... But my colon is super sluggish as I've mentioned before. I just don't understand my sm bowel doing the twisting.. until I vomit. Once it starts, it escalates until I'm empty, then I'm symptom free and no more twisting until I eat something that doesn't settle again.. My old family/surgical Doc in Montana believes I have an adhesion on the outside of my bowel connected of course to another part of my internal self and the gut flops over itself and causes a temp obstruction or maybe the mesentaric artery will lay across my sm bowel and causes it. He swore at first that it was pyloric stenosis.. but it wasn't. I am open for any help in finding out what is wrong with me.Sorry this was soooo long. Belinda
 

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quote: I've had another upper GI series in Aug and no obstruction has been found.
I'm not impressed by upper GI.
quote: But my colon is super sluggish
Why do you think it is sluggish?
quote:My old family/surgical Doc in Montana believes I have an adhesion on the outside of my bowel connected of course to another part of my internal self and the gut flops over itself and causes a temp obstruction or maybe the
You should probably be evaluated with enteroclysis or helical CT to rule out physical obstruction/adhesions.
 

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Discussion Starter · #15 ·
Flux, thanks for your reply.The sluggish colon has been 'told' to me by 2 GI specialists over a twenty yr period and I'm only repeating the quote. It would only seem to passify my eternal struggle with constipation. I was however treated with Librax in my later teen yrs for spastic colon.I'm not familiar with the tests that you wrote of: [enteroclysis or helical CT to rule out physical obstruction/adhesions]But will surely research them. I am calling the University Hospital in Birmingham AL this morning to schedule an appt as my GI in Chattanooga, TN has referred me per my request. Maybe with it being a medical school and research hosp, I may get a broader scope of tests. Seems when a doc gets a DX in his head, it's there to stay. My GI only tells me to increase the Miralax when I complain of the twisting and vomiting becoming more frequent. (encouraging huh?)The GP in MT is set ONLY on doing surgery... of course the chances of opening me up to release 'an' adhesion is like looking for a needle in a haystack.... since I have enough for the entire neighborhood. Besides the fact that once ALL the adhesions are released, I'm guaranteed a whole new bunch of them. I'm very discouraged and desperate for a real DX. I was thrilled that maybe I was done and it really was IBS-C as diagnosed, and I could treat a real problem without anymore invasive surgery. But as I KNOW my luck has it to add another beauty mark to belly!In my desperate readings of this wonderful message board, I haven't come across any except joan that had the visible gut twisting or anyone that suffered with vomiting due to the twisting.Have you?Discouraged but greatful for any opinion out there.Belinda
 

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quote:Maybe with it being a medical school and research hosp, I may get a broader scope of tests.
Can you go to Vanderbilt? If so, you want to see Howard R. Mertz, M.D., GI Clinic, 615-322-0128
quote:In my desperate readings of this wonderful message board, I haven't come across any except joan that had the visible gut twisting or anyone that suffered with vomiting due to the twisting.
As you can see it exists, but is unusual. It can happen in pseudo-obstruction, but not in IBS. There is no easy way to know, however, if you what is causing it is a real obstruction or pseudo-obstruction or even both.
 

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Discussion Starter · #17 ·
Flux,Unfortunately I am a resident of Alabama and have no insurance. I have been unable to work due to illness, therefore unable to carry insurance... what a paradox. The UAB supports people like me with programs for indigent uninsured. Chattanooga also has the programs but I would need a real address for 30 days in their county and state.Is there someone that you could recommend at UAB?I'm stuck between a rock and a very tight space. I have just moved to AL in June from CO so I don't know any 'GOOD' MD's.Thanks again for all you've helped with.Belinda
 

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quote: Some Docs say that Levsin and Levbid are the exact same drug.... but Levbid is hyoscyamine hydrochloride and Levsin is Hyoscyamine sulfate.
If both are hyoscyamine, they should have very similar effects. The hydrochloride vs the sulfate salts may have somewhat different solubilities, absorption/potency, or stability.
 

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quote:Is there someone that you could recommend at UAB?
I just remembered there is Jack DiPalma who is at University of South Alabama. Appointments - (251) 660-5555.
 

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Seeing your colon spasm is fairly common with IBS -- on rare occassions, I have certainly been able to see it or at least to put my hand there and feel it myself. The vomiting, though, is not so common. I hope you find a good GI who can figure out what's going on. Sounds like at the least you have another problem in addition to IBS -- or perhaps you don't have IBS at all. I know how frustrated I have felt just with IBS, and can't imagine your own frustration. On the assumption that you have IBS and some other problem, I would try the strict IBS diets that are recommended here. They can't hurt, and may help your symptoms. You have to be absolutely strict, though. Cutting dairy down to once a day won't do it. Maybe it will make you feel a little better.Best of luck with the doctor. Let us know how it goes. :love:
 
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