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Discussion Starter · #1 ·
I keep on searching the net for any news. I know there are one or two drugs in the pipeline but can't find any further information. Can someone provide me with links/information?
 

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i don't know what's in the pipeline in germany, where you are. with the exception of the vibrating capsule, the following are in the usa pipeline, just google for more links and info on these---lots of info online.

that vibrating capsule in development in israel (not in usa pipeline AFAIK) :

http://www.usatoday.com/story/news/nation/2014/05/04/constipation-vibrating-capsule/8513473/

http://www.vibrantgastro.com/index.php?pid=3

velusetrag

http://www.theravance.com/gastrointestinal

http://en.wikipedia.org/wiki/Velusetrag

elobixibat

http://www.iffgd.org/site/news-events/news/industry-news/elobixibat

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4107709/

http://adisinsight.springer.com/drugs/800029037

plecanatide

http://www.synergypharma.com/drug-pipeline/plecanatide

tenapanor

http://www.prnewswire.com/news-releases/ardelyx-reports-positive-results-from-its-phase-2b-clinical-trial-evaluating-tenapanor-in-ibs-c-patients-277714701.html

http://www.ncbi.nlm.nih.gov/pubmed/26065434

relamorelin

http://www.prnewswire.com/news-releases/rhythm-presents-positive-phase-2-study-results-for-relamorelin-for-chronic-constipation-719659361.html

SYN-010

http://www.syntheticbiologics.com/2014-09-16-Synthetic-Biologics-Statin-Class-Candidate-for-Constipation-Predominant-Irritable-Bowel-Syndrome-Detailed-at-

Companys-Investor-Day

http://www.syntheticbiologics.com/product-pipeline/microbiome-focused-pipeline/syn-010

...and i'm still hoping prucalopride is in the usa pipeline somewhere...

hopefully someone else can add to this. i don't have a lot of time to dig around right now..maybe later.
 

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i don't know what's in the pipeline in germany, where you are. with the exception of the vibrating capsule, the following are in the usa pipeline, just google for more links and info on these---lots of info online.

that vibrating capsule in development in israel (not in usa pipeline AFAIK) :

http://www.usatoday.com/story/news/nation/2014/05/04/constipation-vibrating-capsule/8513473/

Vibrating capsules?!? I could just see when it passes my prostrate, and me having having multi-orgasms, all while doing something like praying in church.

"What's that?!?"

"Ut-oh!" (Hey-now!) lol!!!
 

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oh Flossy--too funny!
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right after the news of this magic pill came out last year, steven colbert had a wildly funny sketch on his show about it. he called this his "number one story--or raher number "two story" that night and he advised that rather than use this pill, just put your cell phone on vibrate and put it up your butt lol and then call yourself....gives new meaning to the phrase "the call to stool"....

his sketch is in this show, right after the beginning (one minute 12 seconds into it)
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http://thecolbertreport.cc.com/videos/p4t1a2/vibrant-constipation-pill
 

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Discussion Starter · #5 ·
Thanks very much annie.i am currently trying the resolor. Helps, but it isn't the final solution for me. I keep on trying until i find a solution. How do you say annie? Hope springs eternal!!!
 

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glad you are trying resolor and that it's helping a little but sorry it isn't the whole solution for you. if you're taking the 1 mg, try 2 mg dose.

I've read some people take resolor with miralax (movicol) or some other osmotic laxative or a stool softener or even magnesium (tablets or natural calm etc) and it works better for them that way. the osmotic helps soften things up and the resolor pushes it out.

I've also heard a few people say that resolor can take two or three weeks to get into your system and start to work fully...but, then, we're all so different in how meds work on us..

yes, it's a lot of experimentation and trial and error, isn't it. and oh yes--hope springs eternal! if it wasn't for hope--and faith--i'd have nothing. keeps me going.
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keeping you in my prayers!
 

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i'm going to try to keep this thread up-to-date and (thanks to kc99 for the information!) adding another med currently in the pipeline:

YKP10811--a serotonin 5 HT 4 receptor agonist

http://www.healio.com/gastroenterology/motility/news/online/%7B2e6c22df-43e4-42bd-b011-122a53cb3820%7D/ykp10811-improves-bowel-function-in-patients-with-functional-constipation

http://www.ncbi.nlm.nih.gov/pubmed/25148765

also--the vibrant capsule is now in clinical trails in the usa

https://clinicaltrials.gov/ct2/show/NCT02030756
 
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thanks for starting this topic, Nuffa
smile.png
. it's a good one to have on the board.
 
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thanks, Nuffa! this drug sounds very promising. there's always hope!
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linzess news:

a new and supposedly better formula of linaclotide (linzess) is in the pipeline--linaclotide colonic release-1 (CR1). looks like it's supposed to be better for abdominal pain relief.

http://www.allergan.com/news/news/thomson-reuters/ironwood-and-allergan-report-topline-phase-iib-(1)

http://www.bizjournals.com/boston/news/2016/12/22/cambridges-ironwood-reports-positive-data-on.html

also -- a new low dose 72 mcg form of linzess:

http://globalpharmaupdate.com/fda-accepts-to-review-snda-for-72-mcg-dose-of-linaclotide-in-chronic-idiopathic-constipation/
 
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