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The 5-HT4 agonist PCS12852 is currently in development for motility disorders and preparing to go into phase 2 clinical trials. The lead indication does not seem to be IBS-C as there have already been previous approvals of other 5-HT4 agonists, but instead Processa Pharmaceuticals are looking at post-operative ileus, opioid induced constipation, chronic idiopathic constipation for now. As currently approved 5-HT4 agonists do have some safety concerns and dosing limitations, this is a potential future alternative to keep an eye on for IBS-C patients.

Sorry for not fixing the treatments in development post but I struggle with making a sensible layout, anybody got some ideas?
 
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