My g/f was one effexor for a while, and it seemed to be ok at first, but when she tried to get off it... it was bad. I think it has withdrawal symptoms, she stepped down just like they told her to, but I saw her just cry and cry for almost two weeks before she felt better. I would avoid it unless it was life and death...Also, I dunno if it's similar to effexor, but I took zoloft and it made my stomach worse (d)... If you are depressed, you might look into 5-HTP, or something similar?Good luck,ben