It has been 6 years since my life radically changed. I battled IBS for 9 years of my life having to quit 6 different jobs due to my symptoms and having been house bound for 1 year. I tried every medication and therapy I could find during those 9 years but to no avail. The only treatment which successfully treated my IBS was amitriptyline. I was never offered this medication as an option for my IBS during those 9 years even though many studies support its efficacy. I requested that my doctor prescribe this drug after finding success stories on similar IBS forums. I am wondering if others have had a similar experience as I have. During those 9 years I was prescribed many different anitidepressants (mostly SSRIs) even though there is little scientific evidence of these medications improving IBS-D. I am now 37 years old and living a full life as my symptoms radically improved after 6-8 weeks of beginning Elavil . I discontinued using this medication 2 years ago and my IBS has not returned. I would like to hear from anyone who has had a similar experience.