Real science has discovered that the immune system of the gut is instrumental in removing ingested substances are generally regarded as toxic (e.g, bacteria cause gastroenteritis). It it performs this removal process at least in part by mast cells degranulating and releasing histamine which causes diarrhea.Real science has also discovered that the brain is wired to the immune system portion of the gut and it appears that the brain can utilize this mechanism to rid of the gut of material when it is sees fit, that is in times of stress.Thus a potential mechanism for bringing about IBS symptoms is through the brain misusing the gut's immune system.I believe that Mike believes that food plays a major role in inciting the gut's immune system and the immune system magnifies this by responding inappropriately to food.Real science has yet to establish this claimed connection. Part of this is because it is difficult to test experimentally. This is because symptoms fluctuate and because of possible "placebo" responses. Double-blinded trials are ideal, but it is not easy to feed someone without their knowing what it is..The other reason is probably because for the most part there is nothing to discover. That is, it may be for a very few people diagnosed with IBS there is something involved with food but for the vast majority it is not the case (as Mike wants us to believe).The gut normally has responses to what is put in it. In IBS, these responses appear to be abnormally exaggerated, leaving one to believe incorrectly that what is put in is the culprit rather its simply being the temperamental nature of the "IBS gut".