Look at the dates of these studies. Also some weren't controlled and in others a lot of information is missing. If these patients were diagnosed with IBS is wasn't under the Rome criteria as they did not have that then and used a different criteria. Also on any food studies I would like to see a follow up after a couple years. That would be interesting to me.Also the active top IBS investigators aren't real scientists, last time I check there were three top immunology scientists studying the exact mechanisms were talking about. Not to mention the top scientist on the ENS or gut brain and others in all fields."At least science is far enough along now to know that all (3) are ionvolved!! This is a big step." Your right about this, but it is believed from the most cuurent research from top IBS researchers that the Brain-Immune reaction is one of the most important players in D symptoms via this reaction.As Flux said perhaps for a very few food maybe in part the culprit for this."Thankfully the investigation into the key role of proinflammtory activation in IBS is not being conducted solely by one group and from one perspective." This has never been the case. Studying IBD, IBS and other conditions gives input into the real science behind these conditions and there are many active IBS researchers from all fields and in different parts of the world, working in conjunction on the problem and there is a internationally known and respected immunologist working on IBS among others.We post this and Mike just seems to ignore it. I think in part because it does not help the focus on food but many other mechanisms in immunology and IBS.The scientist also know there is a really high percentage of food phobia in IBS. I don't think I have ever heard Mike say that? Or that IBS is cyclic and can disappear for years and come back regardless of a persons change in diet. Or that there is a very high placebo rate in IBS which also plays into some of this.If in part all this was the case when you isolated and removed the foods, should the person not be "cured". Or is there more to IBS? They can give Rats a kind of IBS and about 30 percent of IBSers have IBS from gastroenterists or some other shock to the digestive system. If you don't eat an offending food at all and were to inflate a ballon rectally and inflate it you would have pain from a different mechanism and certain parts of your brain lite up.You have to read the science abstracts very carefully for wording as well, such as the ones above. they are very careful what they say most times."Later they went on to study cromolyn sodium instead as an imunomdulator and got results in up to 95% of the subjects stduied depending upon dose and selection criterion." This study had flaws in it.You would think these studies presented here would be interrgrated it into the current IBS research and information since there from the 70 and 80's, and I am sure they are in some ways. They also understand way more now about serotonin and its crucial role in IBS and that its being dysregulated. Perhaps one of the most important chemicals in IBS, athough there are other players, serotonin is responcible for Peristaltic Reflex and others mechanisms and symptoms. You don't here him talk about this much if at all and all of this is connected to IBS and the importantance of other cells like the enterochromaffin cells, are crucial in symptoms. Soon as the bowel expands before food hits the gut serotonin is being released dysregulated and causing symptoms.As for the immunology aspect. If you are stressed or have an attack, caused by anything, hot weather, a food, stress etc.. And you have d, the sensations of having to go, are registered and processed in the brain and this starts an alter immunological responce via the brain which releases a chemical that trips the whole HPA access and releases histamine that gives you d.What I am posting here is a couple years old and they have studied this in much more depth now and have a much better understanding of its is a major player in IBS.IBS is a prolonged stressor. http://www.med.ucla.edu/ndp/Newsletters/Wi...teredStress.htm Food is a trigger and we all now that. I personally have nothing against Mike or leap,maybe some of the information he posts sometimes, but if people want to try that route, so be it and hopefully they feel better.