I have been using Esdifan for only a few days now, but I do have to say that it seems to be working. I want to use it for a while longer before I say that my D is absolutely under control, and, without JINXING myself, the D seems to be gone for now. As a matter of fact, last night I had Taco Bell and so far, this morning I feel fine. I'll have to see how it goes within the next few days, but I think if you have a problem with D, you should definitely give this a shot. It seems from the research I have done on the ingredients in Esdifan, it seems to have less of a chance of side effects and drug interactions than even Immodium. Well, that's it for now. I'll keep you posted on how things go.