I haven't been on here for awhile..because I've been feeling so much better...not perfect..but better. I'm taking 20mg of paxil in the mornings. I have IBS D and have had, for 20 years. I still take immodium occassionally. My life is much more manageable on paxil... way less bathroom mapping! I truly believe the serotonin levels in the brain-gut connection affect ibs. I've gained 8 pounds in 5 months but hey....its been worth it.