One more study which says flatulence is due to higher fermentation in the colon. it is surprising that basal fecal fermentation is higher in normal subjects while the difference between basal fecal fermentation and fecal fermnentation with lactulose was higher in the patients with flatulence. Also the fecal fermentation with lactulose was higher in patients than normals. This was a pretty large study with 126 patients and 30 normals. i wnder what lower basal fecal fermentation means. http://www.ncbi.nlm.nih.gov/entrez/query.f...t_uids=15241490 The first study was directly related with IBS patients Abnormal colonic fermentation in irritable bowel syndrome."Colonic-gas production, particularly of hydrogen, is greater in patients with IBS than in controls, and both symptoms and gas production are reduced by an exclusion diet. This reduction may be associated with alterations in the activity of hydrogen-consuming bacteria. Fermentation may be an important factor in the pathogenesis of IBS." http://www.ncbi.nlm.nih.gov/entrez/query.f...st_uids=9777836
Flatulence And Colonic fermentation
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I don't understand the numbers either except thisThe mean of FFB +s.d. of normal subjects 1.82+1.55 The mean of FFB +s.d. of flatulent subjects 1.24+1.40 ml of gas/24 h; Mean of FFL +s.d of patients with flatulence 8.84+5.55 vs. Mean of FFL +s.d of normal patients 5.72+3.72 ml of gas/24 h, P: 0.004; and Mean of the difference between FFL and FFB +s.d of patients with flatulencwe 7.60+5.05 vs .Mean of the difference between FFL and FFB +s.d of normal subjecta 3.91+3.22 ml of gas/24 hI am not sure how the p's are related except they may be comparing the difference of two means. I don't know how they determined if a person has flatulence
I don't understand the numbers either except thisThe mean of FFB +s.d. of normal subjects 1.82+1.55 The mean of FFB +s.d. of flatulent subjects 1.24+1.40 ml of gas/24 h; Mean of FFL +s.d of patients with flatulence 8.84+5.55 vs. Mean of FFL +s.d of normal patients 5.72+3.72 ml of gas/24 h, P: 0.004; and Mean of the difference between FFL and FFB +s.d of patients with flatulencwe 7.60+5.05 vs .Mean of the difference between FFL and FFB +s.d of normal subjecta 3.91+3.22 ml of gas/24 hI am not sure how the p's are related except they may be comparing the difference of two means. I don't know how they determined if a person has flatulence
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The less gas I seem to have, the more it seems to stink, does that add up?1.82 + 3.91 = 5.72 isn't that 5.73
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The less gas I seem to have, the more it seems to stink, does that add up?1.82 + 3.91 = 5.72 isn't that 5.73
yes.
Information regarding this comes from http://www.ncbi.nlm.nih.gov/entrez/query.f...t_uids=10925977 What they found is that in their IBS subjects, there is more gas present in the gut at any one time. However, interestingly it was not related to the sensation of bloating. We don't know if the rate of gas production or input (from the atmosphere) is any different because it is likely based on other studies, that it's the rate of transit of gas that is inefficient (aka the infamous "trapped gas")
yes.
Information regarding this comes from http://www.ncbi.nlm.nih.gov/entrez/query.f...t_uids=10925977 What they found is that in their IBS subjects, there is more gas present in the gut at any one time. However, interestingly it was not related to the sensation of bloating. We don't know if the rate of gas production or input (from the atmosphere) is any different because it is likely based on other studies, that it's the rate of transit of gas that is inefficient (aka the infamous "trapped gas")
Flux, I was thinking more that fermentation causes gas bubbles and altered transit in IBS traps the gas in pockets, which distends the colon, which is PRESSURE sensitive to ALL stimuli and when the colon distends from gas bubbles or just distension, it can cause pain.That was my thoughts at least.
Flux, I was thinking more that fermentation causes gas bubbles and altered transit in IBS traps the gas in pockets, which distends the colon, which is PRESSURE sensitive to ALL stimuli and when the colon distends from gas bubbles or just distension, it can cause pain.That was my thoughts at least.
"However, the tolerance to the intestinal gas load differed markedly, depending on the site of distension; perception remained low during rectal distension (2.6 +/- 0.7 score; not significant vs. control) but increased during duodenal distension (4.4 +/- 0.7 score; P < 0.05 vs. control). " http://www.ncbi.nlm.nih.gov/entrez/query.f...t_uids=12946941 It seems that it is more lkikely that duodenal distension causes perception rather than colonic distension.
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