Hi BQ. I read your post about the removal of Lotronex. You referred to your bad gallbladder and that sparked my curiousity. I have had IBS for 20+ years. I never had the pain or cramping that everybody else talks about - just urgency and about 4 or so bouts of D per morning.I recently had my gallbladder removed. For the first time ever I had horrible days with severe cramping, pain and horrid D. Since that occurred, I have been taking Questran with incredible results (better than Lotronex). Have you ever taken it? I just wanted to bring it to your attention if you didn't know about it.There was an article posted about it even helping people with dysfunctional gallbladders - so you don't even need to have it out for the Questran to work. I hope this helps you.