For those who suffer from this annoying problem (often accompanies IBS) I am very happy to report I've found some relief. I'm taking a very small dose of Amitryptiline(spelling??) 1/2 pill of small dosage (I think 5 or 10 milligrams) prescribed by my GI doctor. I am peeing much less often than before and don't feel on edge all the time b/c i don't have to pee!-imagine that!! Its great. I tried this before and it didn't seem to work. This is my 2nd try and its working very well. Go figure.