I think that sometimes, at least in my husbands case, that he has been misdiagnosed with IBS. Here is my theory. He has chronic diarrhea. 6-12 movements a day, everyday usually with very little warning. Nothing helps except questran. Questran has made it so there are no symptoms. So does he have IBS or not? I think not. If questran works, then to me it's an excess bile problem. I think one of three things is going on.1)His liver makes too much bile.2)His gallbladder isn't working right3)The bile(for some reason) isn't returning back after use and is being dumped in the colon.There are no symptoms now for months. No matter what he eats, how stressed he gets, nothing. I can't believe this questran is an answer to IBS because IBS isn't a bile problem or this would work for everyone. The Dr. didn't prescribe this. I called and asked for it for him after reading about it on this bulletin board. I've since spoken to this Dr. about this and the bulletin board and the calcium that seems to help so many. He was shocked. He now has his patients try calcium first then questran for chronic diarrhea. I think he is kind of stumped as to why these are working or if he is even diagnosing people correctly. Much more needs to be done to assure that physicians know the criteria for IBS. I feel sorry for people who have complete faith in doctors and don't question things. If we did that he'd still be spending his life on the toilet.