[Guest]

I ran across a reference recently while conducting a MEDLINE search which might be interesting to the group. An article published in the medical journal Digestive Disease Sciences (September 1999, Vol. 44, pages 1893-1898)looked at 20 subjects who either had D-predominant IBS or chronic D were treated with drugs which inhibit gastric secretion. Proton-pump inhibitors such as Lansoprazole, or histamine blockers such as Zantac, Pepcid or Tagamet. Here's a quote from the abstract: "All patients had rapid, marked improvement. Usually, within three days, their symptoms abated and they usually had one to three formed stools per day. Relief continued during the one to six months they were followed on therapy". The authors concluded that: "inhibition of gastric secretion effectively controls the diarrhea and postprandial urgency associated with IBSor functional diarrhea, probably by diminishing the gastrocolic or gastroenteric reflex".Sounds like something to ask the doctor about. Anyone out there tried this?

 

[luckylou]

Guy, an informative article. Will be interesting to know if any of those meds have helped anyone? Thank's for the post.

 

[JeanG]

Thanks, Guy, and welcome to the Board! Jean------------------"Never let the fear of striking out get in your way." Babe Ruth. And I'm also Praying with Bettie for a cure for this NASTY IBS! Jean

 

[Guest]

Have tried them. No help for me. Unfortunately.Skeeter

 

[Guest]

I used Pepcid for a while. It seemed that taking it after supper was beneficial to sleeping but then I was getting really loose stools in the morning, which was counterproductive. I haven't tried Zantac but a few times and it seemed to work better.

 

[eric]

Guy, thanks for posting this! I was talking to Up and Down about it. I sometimes found relief when I was on Tagament and they thought I had ulcers,and I wondered why it worked sometimes for me, not all the time but it seemed to help. It was prescription strengh though, not OTC. I don't however like some of the things they say about tagament though in long term use. Thannks for this though.------------------ http://webpotential.com/ericibs/index.htm

 

[eric]

Guy, thanks for posting this! I was talking to Up and Down about it. I sometimes found relief when I was on Tagament and they thought I had ulcers,and I wondered why it worked sometimes for me, not all the time but it seemed to help. It was prescription strengh though, not OTC. I don't however like some of the things they say about tagament though in long term use. Thanks for this though.------------------ http://webpotential.com/ericibs/index.htm

 

[Guest]

Guy -- nope, sorry, but thanks for the info. during the past year, I've been on Axid, then Zantac, then Prevacid (one of the strongest acid blockers there is). when first treated, the bowel movements were normal for about 5 or so days. then, my system suddenly got worse than ever. for me, the prolonged use of such medications apparently turned my loose stools into nearly completely uncontrollabe D (or mush), which is one of the known side-effects of that med. for some.it does stand to reason, however, that that med. might help some people for a while -- because one of the reasons for D is too much acid in the system. [This message has been edited by JanetMD (edited 11-21-1999).]

 

[flux]

Too much stomach acid shouldn�t cause diarrhea unless there is something major going on (e.g, Zollinger-Ellison syndrome)

 

[Guest]

Flux -- What?? What's Z-E syndrome? Never heard of it. How come I've heard over and over again, and know I've also read, that an overacidic system can contribute to D? I guess several of us here could also have Z-E, then?!?[This message has been edited by JanetMD (edited 11-22-1999).]

 

[Blair]

Prilosec was given to me for an ulcer and it helped with my IBS D. I also take questran. I still have to watch my diet. I've gained back most of the wieght I had lost previous to the prilosec because the nausea is way down. Still got the IBS though and its a tough thing to treat.