I ran across a reference recently while conducting a MEDLINE search which might be interesting to the group. An article published in the medical journal Digestive Disease Sciences (September 1999, Vol. 44, pages 1893-1898)looked at 20 subjects who either had D-predominant IBS or chronic D were treated with drugs which inhibit gastric secretion. Proton-pump inhibitors such as Lansoprazole, or histamine blockers such as Zantac, Pepcid or Tagamet. Here's a quote from the abstract: "All patients had rapid, marked improvement. Usually, within three days, their symptoms abated and they usually had one to three formed stools per day. Relief continued during the one to six months they were followed on therapy". The authors concluded that: "inhibition of gastric secretion effectively controls the diarrhea and postprandial urgency associated with IBSor functional diarrhea, probably by diminishing the gastrocolic or gastroenteric reflex".Sounds like something to ask the doctor about. Anyone out there tried this?