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Discussion Starter · #1 ·
Generic Ondansentron seems to be substantially cheaper, I found these prices on-line:(The 24 mg price makes no sense, cheaper to take 3 x 8mg.)Anyway, anyone have a sense of what a typical dosage for IBS might be?Anti-Emetic» ONDANSETRON (on-DAN-se-tron) Brand : Zofran (Generic) Composition : ONDANSETRON (on-DAN-se-tron) Zofran 4mg Qty. Type Our Price Other Price Buy 30 Tab $60.99 US $612 US 90 Tab $162.99 US $1836 US Zofran 8mg Qty. Type Our Price Other Price Buy 30 Tab $102.99 US $1017 US 90 Tab $274.99 US $3051 US Zofran 24mg Qty. Type Our Price Other Price Buy 30 Tab $549.99 US $2852 US 90 Tab $1,544.99 US $8556 US
 

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Hey Stuart,I was a bit curious about that myself. I did type Zofran into one of those cost-comparison sites myself and almost all the results were from offshore pharmacies and not the US retail market.The only legitimate price quote I could find was from Walgreens.com, where the 4mg tablets still cost a very substantial $19 a pill. It shouldn't be all that surprising, I suppose, that Dr. Reddy's is going to get as much out of their 180-day exclusivity as they can, but still seems pretty outrageous considering the negligible R&D expenditures they no doubt incurred in getting it approved. It seems like their generic has already captured 55% of the market share from GSK in less than a month, though.http://www.forbes.com/feeds/ap/2007/01/22/ap3348129.htmlNo doubt the price will come down substantially this summer, hopefully to the point where not too many insurance companies would kick up too much a fuss about covering it for off-label uses, though I wouldn't expect the drug to be truly dirt cheap the way that a drug like, say, amitryptyline is.But even if the price goes down it probably isn't too likely that Zofran will be a hugely popular off-label treatment for IBS-D. First, the little published data that exists isn't really that compelling. And second, I remember that Jeff mentioned on one of the older Zofran threads that many of the top docs he spoke to refrained from openly endorsing the use of Zofran for our condition, though I'm not entirely sure why. And that sort of impetus usually needs to come from the top specialists, for example the use of low-dose atypical antipsychotics for anxiety which was started by very prominent psychiatrists and is now getting more common.Still, I think that people with open-minded doctors might want to consider asking about it, and at least from what we have to go on from this board, the anecdotal reports suggest that Zofran is without a doubt much more effective for some people than the usual antidepressants and antispasmodics.As far as the dose, I seem to recall that a lot of people took as little as 2mg or even 1mg a day (don't ask me how in God's name one could split those pills into four pieces and end up with anything but a pinch of white dust.) I think a few people went as high as 16mg or maybe higher but I don't really recall very well. You might want to do a search for "Zofran" of the forums. In any case, no doubt the exhorbitant price was what led people to try the lowest possible dose.Rnaga,Didn't you take ondansetron at some time in the past? And then you were on Lotronex, I recall. I know that generic ondansetron has been available in most parts of the world, including Brazil, for some time now, though I have to confess I have no idea what it might cost.
 

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JJ, that was a great post.I always wondered why my doctor refused to prescribe this to me when I asked. He is known as a pretty well-respected Gastro around our area and has a lot of "pull" in the community. He got me into a clinic in 3-4 days that had a 6-8 month wait.Many of the doctors I speak to tell me how highly regarded he is in the medical profession. "He is smart. He knows his stuff."But that doesn't necessarily mean that they're the "best" doctor to go to...just being smart doesn't mean much.I think in my case, having exhausted almost everything known to gastros for my condition, he would at least consider it (Zofran) due to the shear cost of Lotronex.Where I get my prescription it's $450-500 for a month's supply. I can't afford that.I *could* afford $150-200, though.I am going to inquire about it ONE more time at my next appointment.
 

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This is just amazing to see these prices and realize what you have to pay for these treatments. These are for generics? (Just as a comparison, I paid about $25 a month Canadian to treat myself, and the relief has been anything but partial.)Good luck (and good grief)!Mark
 

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Well, with insurance I was paying $100/mnth for Lotronex because it wasn't on my insurance's formulary list.But since Zofran is, and now that it has a generic, I'd have a $10-20 co-pay per month.But without the insurance it's quite expensive.
 

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When Lotronex was pulled off the market most people who where using Zofran instead where taking 2-4 times the amount of Zorfan ie. 1mg Lotronex users where using 2-4mg of Zofran.The generic is like $2 a packet of 10 cheaper here than Zofran. Medicare has its downsides.
 

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hello~
i thought that the price of the "generic" version is lower because after the patent expires pharm companies other than the original maker of the med are allowed to make and sell (the patent, kinda like copyright, is expensive)... in many cases there are only minor differences between the original and the generic verions... but i don't know that much... so i may be wrong...Hope you find the med you need...
 

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Hello Cherrie.....Nice post and you are right that is how the off patent drugs are supposed to work....cheaper through open market competition.....I loved the Einstein quote....did he actually make it....? The drug companies are so out of control....they make millions and then when the pipeline runs cold they cry that by not extending patents and ripping the poor partients off any longer they have to lay people off and close down plants.....instead of reinvesting into drugs that could continue their market shares....if another company can gear up and make generic drugs at a profit their is no excuse for companies like Pheizer having to close their doors on production facilities....just drop the price...but no that would upset their whole paradigm....two cents please
 

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Discussion Starter · #10 ·
The internet pharmacy that I got those prices from is call Tristatemeds.com. Here is a deep link to the Zofran page:http://www.tristatemeds.com/generic.php?ge...ofran4mg30pillsI know nothing about this company and make no representations whatsoever about their legitimacy. I just wanted to show that someone is purporting to sell Zofran inexpensively.The actual price is the one on the left - sorry for the confusion, it was how the page copied. In terms of whether its helpful, I would risk $60 to try it. Different things seem to help different people, and the doctors rarely know why anything works.
 

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Thanks, Noguts
and thank you for liking the quote! yeah, it's made by Einstein himself (i forgot where, though, probably in one of his conversations with Tagore...
)i totally hear you and understand how it can get for us patients who are suffering and yet have to pay huge for drugs that we use daily... i wish there was a simple sulotion and a simpler situation...i'm a social science major and i don't work for a drug company, though i do believe that a lot of these companies ARE losing money this couple years -- partly it's just like IT a few years back, they are now reaching a lower point of the profit/job market cycle; and it's not even the lowest yet. i have a few friends whose major has to do with pharmaceutics -- since the year before last, job market has been getting tougher and tougher, esp. for new grads who don't have experience in industry... as for the patent stuff... it's really complicated, i heard... the whole process of drug development starts in the basic "discovery" labs in companies and universities, a lot of the times from scratch (but based on previous literature). Those profs/grad students/employees work very very long hours (until 2-3 am is not unusual) and it took many years, dollars, and failures to synthesize something useful typically at this stage in the amount undetectable to the naked eye -- from here on it'll still take a LONG time for them to hone the methodology so that large amounts could be produced (AND, patent begins with the undetectable amount), and even this is still quite a few steps away from the humanly useable drug. If everything works really well and experimental drugs are eventually made, then the process moves to the testing phase -- three stages of them taking quite a few years before it could be approved by the FDA. It is not uncommon for a drug to fail the last stage of testing and so they have to go back and fix the problem and start testing all over again (which is the required and responsible thing to do)... In the end when it gets approved and can be manufactured and put on the market, the fastest drug development in a company would take 7-8 years to be optimistic. if the years in a university lab are counted, it'll be even longer (over 10 yrs). Yet at this point, A LOT of patent time has been spent already, together with the huge dollars on material, equipment, wages, etc.! and with all the rest of the personnel in the company, like administrative, legal, marketing, process, etc., etc., having to also feed them together with the ones who discovered the drug and make a profit for further development, all in the amount of time where the patent is still in effect... which is (as far as i know) why drugs are expensive before patents expire... and every time a drug company has two or more major patent expiration, it's stock will go down drastically and it is almost bound to close some branches... i feel so much for those people who've lost their jobs... it is so sad and yet so unavoidable...
... and since the larger the company, the more intricately connected it is with the policies of the administration at the time, politics is unfortunately also a big factor influencing stocks and profits and drug development... Also, with more and more legal issues, a lot of companies are unwilling to even develop new drugs that'll involve them in high-profile lawsuits or bad rep., which is partly why a lot have turned to cancer research... it's really very bad for us patients eventually, 'cause then drugs for other diseases are not as well researched and developed as they should... companies like pheizer... i don't know... heard that they don't do that much development themselves, but instead they bought other companies and their drugs when they were doing well... but now it's a bad time for all, so they just had to close some...but then again, i certainly don't think that us patients should pay THAT much just to take something for daily relief or survival in some cases -- i personally feel that it's the insurance companies that should cover more... And... don't hate me for rambling so much!
And thanks for reading...
 

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Dear JJohnsonI take zofran in the past with good results. I take lotronex too and i think works better. But in brazil it´s hard get zofran or lotronex. Here i get zofran by R$ 176 (about US$ 80)- 4 mg 10 pills. Unfortunely the site i buy recently get out of the internet i dont know why, but i can find zofran in the local drugstore too and i am looking for another sites and i think its possible get zofran to price i talk about. Other day i find a site list generic zofran 8 mg 10 pills to R$ 55 (US$ 26) but i call to make sure and peopel say they dont have. I dont know if the generic will be sold with this price, as a matter of fact, until now i cant find generic of zofran in brazil. I hope the price go down because now i take little zofran with loperamida (imodium) and works very well, but i take minor doses of imodium and zofran,but i do that because of the price of the zofran.There any news about other medicines: cilansetron, ramosetron. I think if lotronex go to other countries than USA the price could be go down too, because is not cheap too.
 
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