Hi - I am having a problem with taking prilosec or tagamet for GERD. I need to take something continuously but prilosec and tagamet make my IBS sooooo much worse that I almost ended up in the hospital the other night. Has anyone else ever had problems taking these medications? I don't know what my gastro doctor is going to want to do. Plus, my IBS is getting so bad I can hardly function. The pain and gas is unbearable, I am starting to wish that a truck would hit my car on the way home from work.