[20884]

Is GUT permebility in SMALL INTESTINE is affected in IBS patients? i.e. the solute ( electrolytes) and water absorption are normal in IBS?

 

[SpAsMaN*]

Why not,if there is microscopic infflammation?:http://www.cgf.gu.se/fouschema.html

quote:His theory is supported by results from several animal models. For example it is shown that Trichinella spiralis causes inflammation in the motorneurons in rat, and that you can see morphological changes after infection by T. Spiralis. To be able to examine the myenteric plexa you have to take full thickness jejuno biopsies. In a study there was full thickness jejuno biopsies taken from patients with severe IBS. Of ten patients nine had inflammatory neuropathy. For example neuron degeneration was shown in seven patients.

 

[20884]

Trademark Spasman.Nice Link

 

[eric]

This is Dr Splillers comments on the paper Spasman posted.Neuropathology of IBS? http://www.gastrojournal.org/article/PIIS0...004857/fulltextHowever,"But microscopic inflammation cannot be a diagnostic marker for IBS because it does not typically produce pain in those who have it. All patients with active celiac disease have microscopic inflammation, but a large proportion do not have abdominal pain, and patients with ulcerative colitis who also have microscopic inflammation when compared to patients with IBS appear to have higher pain thresholds (24). In individuals with these disorders, there may be central nervous system counter-regulatory measures responding to the peripheral pain/inflammatory processes that increase pain thresholds. With regard to IBS, the gut-related effects of microscopic inflammation may be only one component of a dysfunctional brain-gut system."http://www.romecriteria.org/reading1.html