I was having the same problems. In the past when I was on the Lotronex I was on 4mg a day. Worked great. This time around I tood one pill 1mg in the am for 3weeks. Was having a lot of pain and bloating. Then doc upped me to 2 pills a day. Still the same thing happened and then ended up with 2 severe attacks in 8 days. Had attacks before like that but weeks apart. So went back to the one a day and kept a log. Seemed like no matter what dosage I took I noticed that anywhere between 4-6 hours after taking the pill I started getting cramps, gas, then D. I thought maybe it was a fluke because it worked so well with no side effects before it was taken off the market. Hubby pointed out to me that back then I was still able to function for the most part. Now I am 99% worse off than ever and am lucky if I can go to the store once a month. Other than that I'm mainly housebound. So after 2 weeks of keeping the log I have determined this, I did one week with one pill and one week with 2 pills....Week one:1mg 8am with glass of water, 1pm cramps start2pm gas buildup really bad2:30pm D starts and doesn't stop until completely cleaned out arond midnight.Pain lingers and keeps me awake most of the night.This went on almost every day for a week.Week 28am 1mg with glass water12pm cramping and gasby 3pm bad Diarrhea and nausea5pm take another 1mg pill with dinner (sometimes later, dinner was anywhere from 5-6:30pm)Midnight-woken up with cramping, nausea, diarrhea, up all night with it.I stopped taking the Lotronex on Friday February 21st. The 22nd I wasn't feeling that great still because of 2 straight weeks of pain and D. the 23rd I felt great and got a lot of things done around the house and went out with hubby. Monday took my kids shopping with me for a couple hours. Tuesday stayed home too tired to do much from fibro and ibs was acting up a bit. Wednesday again felt pretty good went out with kids for couple hours just hanging out. Thursday didn't feel good most of morning. Thursday evening wasn't that bad. FRiday was good. Hubby got home early from work (around 4 after he did food shopping on way home) and I wanted to go out. So we went out driving around, went up to Laconia (about 45min drive away)and did some shopping at the outlet malls) and then got dinner to eat in car on way home. Ate Kentucky Fried chicken dinner, but then went to mall close to home and did more shopping, (bought a dishwasher) and finally got home around 10pm. Had a great time.over the weekend we ran errands together off and on throughout the day. Last night however I decided that since I had been feeling pretty good I would try to take one Lotronex before bed. Unfortunately I was woken up at 3am with cramping and felt like I had to go D. Nothing happened until around 5am. Now my stomach is really raw, the D is back, the cramps are there as well as the nausea.So my conclusion to this is after 2 years of fighting, writing letters, signing petitions, calling glaxo on a weekly basis, filling out surveys, etc etc to get this medication back, now I can't take it because it now makes me worse.There is not one other medication on the medical list for IBS that I haven't tried. I have even tried medications for crohns, diverticulitis, etc to no avail. I am doomed to live the rest of my life like this until there is some miracle on my behalf.Hope things get better for you guys