I tried going off my antidepressant this week (Pamelar 25 mg) because it wasn't helping that much with sleep, was making me gain weight, and wasn't helping too much with my stomach pain. Well, my husband bought my some Valerian root. I took it for two nights. (I've had a rough past couple of days since trying to go off Pamelar: worse than ever stomach pain so much I can't eat at all, constant crying and feeling helpless, anger). I do not like the Valerian. I took it last night and still woke up in the middle of the night. Then I finally got back to sleep about 3:30 am. Woke up at 8:30 again and my head hurt so bad I couldn't even lift it off the pillow. I just felt so sick. I think these things are not just the Valerian, but a combination of it and the anxiety coming back in my body. I took one of my old reliable .5mg Klonapins this morning. I just take them as needed. Plus some ibuprofin. I felt fine all day. I'm starting my Pamelar again tonight and skipping the Valerian. I really wanted to try the natural route because I am so frustrated. I think I finally realized that although my IBS is by far not solely the result of anxiety, it is a major factor. I've been reluctant to admit it over the years but I think to be able to eventually get better I need to. I've never tried the St. John's Wort.