I have been on Miralax for years, which worked for a while. But it seems to only get progressively worse. Now I am afraid to travel and I am supposed to take a vacation with my boyfriend this summer who doesn't know about the IBS-C. I have tried Amitiza, Zelnorm, suppositories, enemas, in varying amounts with varying (but NEVER consistent) degrees of success. I try to exercise a lot and I do yoga as well. I have even been to Mayo clinic and physical therapists. Nothing is consistently working. Usually Dulcolax works as a rescue med, but every so often it doesn't and it spirals out of control, which it is doing now. Which sucks, because I have to move this weekend. I have also tried probiotics - nothing. I have tried flaxseed, Udo oil, nothing. Loading up on fiber makes it worse. I should say that usually I have incomplete evauation, usually of mushy quality. Can anybody please tell me something else that has worked for them? I am desperate. I have a good life - I just got a Master's degree and now going for the PhD. Great boyfriend (only been dating for 2 months and I've hid this from him as best I could), great family. But when this gets bad I hate my life and have contemplated (so far not seriously don't worry) suicide.I thought maybe you all could help. I've never been on a help group site or anything like this before. Any help is much needed and appreciated.