First posting on the forum, though I've been reading here for some time now. Dean, reading your post mirrors mine exactly. Quit smoking after 10 years 16 months ago. Never a problem with regularity before. Since then my bowels have been on "lock down" status ever since. During previous quit attempts, I also battled C. While I suspect stress plays a role, I don't believe its the singular cause. I was stressed when I smoked and never had problems with my bowels. Briefly, I'm 32 y.o.. male, no prior health problems and physically active. I am not overweight and eat well (i.e., lots of green stuff on my plate). I've been diagnosed by my PCP as having IBS-C, but my gastro thinks I have slow transit constipation. I think I have colonic inertia. They have rules out cancer, thyroid,diabetes, Celiac, Lactose Inol. I've have not been subjected to any of the "typical" GI doc tests with scopes, swallows, or balloons up the you know what. Based on the info I've gathered from others on this board and doing my own research, I'm fairly confident CI is what I'm suffering with. I will be going in for a sitz marker soon. As an aside, as I describe my symptoms and interventions, I'm curious to hear from others their thoughts, to see if a similar pattern emerges re diagnosis and effective treatments they have tried. During the past several months I've tried Miralax, stool softeners, increasing fiber, probiotics, MOM, Amitiza, Rifaximin, and stimulant laxatives. Each worked for brief periods. Miralax for a couple of months - then only caused horrible bloating and gas. MOM did the same, turned everything into D and then would sit in my colon forever, sloshing around - with more bloating and abdominal distention. Fiber (yuk) worse still! I think the Amitiza helps with the bloating some. I should also say that my stools are never hard, always pencil thin and difficult to evacuate. I even thought I had given myself a hearnia at one point because of the straining. I would go several days without an urge to evacuate. It feels as though peristalsis had ceased in my colon - not good. The only method that produces consistent and positive results in the use of stimulant laxatives. With either senna or bisacodyl I have the urge and will go several times (3-4). With great relief. With the osmotics, it feels as if the liquid stool just sits. Plus given that my stools are not hard anyway, I don't see the point in making them softer. Anyone care to enlighten me on this one. Collectively, this leads me to the conclusion that I had, through my years of smoking, become dependent on stimulants (nicotine is a stimulant). I don't believe its coincidental. What do others think? I'm really curious to hear from others about this. Any similarities/discrepancies in symptoms, onset, and effective interventions?As I wrote above this is my first post and I want to thank everyone who selflessly shares their experiences on this board. They have been truly comforting for me at times when I've felt very alone with this problem. Sadly, there are so many of us suffering and at least we can come here to vent and cry when needed. Thanks again.