I am 42 and have had IBSD since I was about 18 years old. Paxil worked well for about 2 years. It quit working, and I had significant weight gain. Afterwards, I suffered for several more years until I found this website and discovered that calcium could work wonders. Again, another 2 years of relief, and now it no longer works. I was taking one Caltrate tablet 3 times a day and was amazed at how well I felt. But now, I no longer get any relief. I even doubled the amount of calcium, but that did nothing. My doctor recently put me on Bentyl which worked for about a month. I went to see him yesterday, and he changed my medication to Donnatal. I haven't started taking it yet, but fear it will be another drug that only works temporarily. Any suggestions? He told me to take probiotics which I have done in the past, and I couldn't tell that it made any difference. I'm so discouraged, because with Calcium, I thought I had found my "cure."