from what i've experienced myself & from reading forums & researching this nasty disease, when u take some sort of "DRUG" to stop the symptoms of D, all u r doing is stopping the over stimulated spasms of the intestines & not treating why the spasms r out of control in the 1st place............what happens is the thing eventually gets worse.........there is disease activity & u've done nothing to treat or reverse the activity..........if the disease or deficiency is going on, stopping the spasms is like putting a bandaid on an infected sore.........it just covers it up till the infection gets to the point that it comes out of the edges of the bandaid...........it's still there, it's still active & now it's worse..........have u tried tryptophan & or 5HTP..??.............serotonin controls the intestinal health & makes the muscle relaxed & smooth as they should b in healthy tissues that is all muscle..........70-80% of serotonin for the whole body, is made in the intestines..........when, for whatever reason, u r not making enough serotonin, the muscles spasm.........& think about this.........serotonin effects & controls many things in the whole body............not just the intestines..........tryptophan & or 5HTP r the building blocks of serotonin.............the trick is finding the amount that helps u.........the least amount of either for daytime, so u r not sleepy............at nite serotonin gets converted into melatonin, so if u have too much, u get sleepy...........i take tryptophan at nite, u can start with 500mg to c if that helps.........for me, i think tryp has more properties than just making serotonin...........then i take a 100mg cap of 5HTP & open it & divide it up into 1/3rds or 1/2's...........get empty capsules............i take about 35mg, 4x aday............at the 4-1/2hr mark, i start to feel the stuff in the gut that signals D on the way..........if i take the 5HTP then, it stops it in it's track..........the only thing that u have to know is, if u don't take some nutrients & have them in ur bloodstream, the tryptophan & 5HTP will not b made into serotonin..........they r:.........chelated magnesium, B2, P5P (the active form of B6), niacin/niacinamide & a little vitamin C...........i take them with other herbs & vitamins, 2x aday.........if u take them with the tryp or 5HTP, u only need small amounts of these things...........but they do lots of other things in the body besides helping to do the conversion, so they r good to take anyway...........when u 1st start, u might feel like u r on a roller coaster..........when u r deficient in serotonin, many things r not right, even ur emotional equilibrium...........if u can, start on a day or 3 of time u r going to stay home anyway..........get ur body flooded with these things...........take the 100mgs 5HTP as often as u feel like u r going to have D, so that u can flood the whole body with serotonin...........take the tryp at nite, b 4 going to sleep..........i'd start out with the 5HTP 4x aday.............u may catch up on ur solid, sound sleep..........the more they effect u, the more u need it...........it's been my experience that when we r deficient in something vitally necessary for our physical well-being, the larger & more intense the reaction...........u may not need it as much as i did & only get the relaxation & sleep...........one more note::.........i'd increase the tryptophan at nite, SLOWLY, till u r sleeping thru the nite & waking up w/o D in the 1st hr.........i had to open cps of tryp & start out at 83mgs of it, they don't sell it in less than 500mgs.........get pharmaceutically pure.........do the research on it..........5HTP comes from a plant & seems to b standard, but get a name brane.........u can find 50mgs of 5HTP, but till u find the amount that works for u, u need to experiment with the amounts of these things..........my body is very sensitive to stuff, this is why i had to start out with the low amounts.............try to remember, this is not a drug & if u r in need, u may need to take these for the rest of ur life..........it also means there is other things going on in ur body that is causing the lowered serotonin production............i'd do alot of research on these things..........but try the tryp & 5HTP 1st, it may b the ticket...........it has been fantastic for me & others i've come across........ complete digestion is a big part.....betaine hydrochloride might help with this...........