Hello Jen: You are lucky to have found these boards as most of us here share what is happening to you. Many have suffered for years as well. At one point, I was stuck basically 10 feet from my bathroom for 8 months and lost more than 30 percent of my body weight. I think in order to truly offer advice, we would need more information such as: 1. What types of prescriptions or medications you have tried in the past? 2. Any herbals you have tried, 3. Do you have food allergies or know of foods that seem to make you worse? 4. Do you have alternating constipation and diarrhea or pretty much just D? 5. Do you have other symptoms such as pain, weight loss, blood loss, burning, gas, bloating, acid reflux or other medical/health conditions? 6. Have you been seen by a doctor and diagnosed with a GI problem and if so, what did they say and what types of tests have you been through/what has been ruled out?We are not here to replace the advice and recommendations of medical professionals. However, there is so much here. I have tried a number of the recommendations and gotten relief from horrible IBS-D and SIBO (small bowel bacterial overgrowth). If you have not ever seen a doctor regarding your problem, you should. There can be other conditions more serious that should be ruled out via GI exams, blood work, stool cultures. Some things that can relieve diarrhea and this is just a short list and it can be any one or several that work (Most take time - up to three weeks to see some benefit besides imodium). Also, adding and switching too many things at once can often result in not really knowing what helped you and what caused more problems:Imodium - take the max dose prior to going out - this seems to work regardless of what problem you have unless it is infectious or inflammatoryAvoid all dairy food, cheese, yogurt, casin and cassinate (pastry/bread/packaged food items) - one in four people cannot tolerate dairy of any kind and it is NOT just the sugar, it is the proteinAvoid Gluten (Wheat products) - Tests can be done for Sprue but some people are just sensitive to wheat/glutenFloragen - a good proboticKilfur - another probotic but it is dairyBubbies Sauerkraut - another live probotic at Whole FoodsHaung Lian Su - an antibiotic type chinese herb available on AmazonVarious IBS formulationsZincLysineGlutamine PowderGas-XCalcium carbonate plus D vitamins - great to form stoolsD supplementspeppermint caps - freeze and take with meals grapefruit seed extract drops as a natural antibiotic to kill bad bacteriaHCi tabs - extra stomach acid to kill bacteria in the small bowel to be taken with food but NOT if you have an ulcerRx antidepressants to control gut motility - many products work quite wellCodeine Rx to create constipationAntibiotics such as Tetracycline, Cipro, or Xifaxan if you know you have bacterial overgrowth of the small bowel or too much bad bacteriaDigestive enzymesRx Cholestryramine - a powder that is used if you have too much bile or Habba SyndromeBiofeedback and relaxation techniques or drugsAntiacids/PPi's if your problem is actually an ulcer, gastritis or too much stomach acid Check out the section on Prescription Medications to learn more. Organic clean diets and/or strict dietary modifications - some people have done very well with raw food diet. I have done better on all organic food, adding organic flax seed freshly ground, taking the calcium and vitamin D tabs, antibiotics when I'm really bad (but I have SIBO), imodiium for meetings and flights, avoiding coffee, alcohol, dairy, sugar and limiting processed grains. Basically, I personally eat nothing but organic fruits and veges, a few whole grains such as oats/oat bread, flax and organic grass-fed meat. Good luck.