The problem is that diferent things work for diferent people. For better or for worse IBS conditions can be extremely diferent from one another, and sadly treatments for some cannot work for others. I can tell you what I am taking, but theres no guarantee it will work for you. I am taking Hyosycamine and Amitripiline. However the Amitripiline is extremely tiring and can interfere with yuor sleep patterns a little(I'm an insomniac ontop of that!) and can really throw you off for a little bit(I was prescribed it in february and I'm still coping). I usually go to sleep at 12:30-1AM and I wake up at 5:30-6:00AM, which I got used to until I got this drowsy stuff. So now, I also sleep from 4:00-6:00PM when I get home,hehe. But theres no guarantee any of it will work for you, talk with you GI about what he/she suggests. Raven