Suzie, I started out the first week taking 12mg, 6mg morning, 6mg at night. By the end of that first week I was very uncomfortable and disappointed. Second week cut back to just the nighttime dose and added a packet of Lactulose. Still pretty bloated, but better. Third week, everything just seemed to ease, began to have some regular bowel movement, and most importantly, the bloating reduced substantially, it's SO nice to have a flat tummy! I've been eating an apple a day, and oatmeal in the mornings, salads and lean meats.I take the Zelnorm an hour or so before eating dinner, and drink the Lactulose after dinner. I tried taking the Zelnorm before bed but without something in my stomach it made me a bit queasy.In the mornings I have a cup of hot tea and a glass of iced tea, wait a bit, then prepare a small dish of oatmeal and have anther cup of hot tea and glass of iced tea. Following this regimen I've become quite regular and so very much more comfortable. Before, my eating habits had become erratic because of the discomfort, and I was afraid to eat salad, fruit, rice, because I'd inflate like a rubber raft and cramp up like a colicky horse. It was hard even to drink much liquid because of the gurgling and feeling of fullness, seemed like I was just doomed to always be constipated, my intestines just didn't have enough fiber, water, or motility to function.If it doesn't work at first, hang tough and give it a decent run, three weeks at least. And don't be afraid to add something like Colace or Miralax, by itself it may not take care of the chronic constipation, but it sure does make it possible to introduce and tolerate foods and other meds that do.
Good luck, let us know how it works for you.