I've had very little success with hyoscyamine for pain reduction. I have IBS-C due to impaired motility with severe pain. I've had good success with pain reduction using a low dose of the tricyclic antidepressant (TCA) doxepin (generic name). I take 50 mg each day after dinner. The recommend low dose is 25mg to 75mg. Main side affect was drowsyness which improved over time plus taking it in the evening helps as well. It would feel like some one had a knife in my gut and was twisting it around, pretty much all the time, even at night, the pain would wake me up. The doxepin has greatly reduced the pain...now if I could just find something to relieve the constipation. LOLI don't know if you are experiencing constipation or diarrhea. Imipramine or amitriptyline (both TCAs) are recommended for diarrhea predominant IBS. Doxepin or desipramine for constipation predominant IBS. There have been several medical studies on the use of low dose TCA on pain, check out some of my other posts and you will find links to these articles.I would hesitate before trying something as strong as Cymbalta, because if it doesn't work, weaning off of it may be difficult for you. I found out the hard way that I am very sensitive to the SSRI's...it took many months to slowly taper off of the SSRI Lexapro, with many withdrawal side effects along the way. Cymbalta is one of those combination meds, combining an SSRI and a SNRI.IBS pain can be very wearing. I hope you can find some relief soon.